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πŒΌπŒ°πŒΏπ‚πŒ²πŒΏπƒ πƒπŒΊπŒ΄πŒΉπ‚πŒ΄πŒΉπŒ½πƒ

πƒπŒΊπŒ΄πŒΉπ‚πŒ΄πŒΉπŒ½πƒ
English: Some serpins can spontaneously convert to an inactive latent state. The serpin PAI-1 remains in the active conformation when bound to vitronectin (green). However in the absence of vitronectin, PAI-1 can convert to the inactive latent state. The uncleaved RCL (blue, disordered regions as dashed lines) inserts into the A-sheet and the pulls the first Ξ²-strand off the C-sheet (yellow). (PDB: 1OC0​, 1DVM, 1LJ5​​)
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πŒ±π‚πŒΏπŒ½πŒ½πŒ° πƒπ…πŒ΄πƒ π…πŒ°πŒΏπ‚πƒπ„π…
πŒ±π‰πŒΊπŒ°π‚πŒ΄πŒΉπƒ Thomas Shafee
Other versions For unannotated version, see File:Serpin latent state (unannotated).png

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